The loss of these anti-atherogenic properties of HDL in patients with diabetes is a consequence of proteome remodeling that includes, among other factors, alterations in the content of apolipoproteins (apoA-I, apoA-II, apoC-III, apoE) and enzyme activities with anti-inflammatory properties (lipoprotein associated phospholipase A2-Lp-PLA2-, paraoxonase-1-PON1-) associated with HDL [8]. The gene discussed is PON1; the disease is diabetes mellitus.