Malaria caused by P. falciparum on the island was primarily multiple infections with generally high parasite variation, together with a high predominance of the K1 and MAD20 allelic families of msp1 and 3D7 and FC27 families of msp2. These findings also indicate that a methodical exploration of malaria prevalence, with full-scale drug resistance surveillance, is essential for effective malaria prevention and eradication countermeasures. Here, ATAD1 is linked to malaria.