INS and hydrops fetalis: Diet also significantly affected the response to intraperitoneal glucose and insulin tolerance testing, with HF mice having higher glucose area under the curve (AUC) values for both the IPGTT (p = 5.16 × 10− 7) (Fig. 3) and the IPITT (p = 2.53 × 10− 8) (Fig. 4), indicating impaired glucose and insulin signaling.