MYC and cancer: We found a ~ 10% reduction in total body weight in the homozygous MD mice, which was not reported by Dave et al. Strikingly, in both studies a strong, tissue-specific downregulation of Myc was observed along with anti-cancer properties against Apcmin-induced polyp formation, carcinogen-induced mammary cancer [23], as well as transgene-induced luminal and basal mammary cancer (this study).