Several point variations, like single-nucleotide polymorphism (SNP) in gene promoter sequences present in the human population, have been evaluated and correlated to the risk of developing neoplasms, such as lymphomas [7–11] or other solid tumors, like cervical, hepatocellular, and gastric carcinoma [12–14] with controversial results regarding the association with the risk of developing a given neoplasm, for example, have a better disease-free survival in patients who lack SNPs with altered IL-10 production, such as − 1082 (G/A) [15]. This evidence concerns the gene IL10 and gastric carcinoma.