We consider that although no association was found among diverse SNPs from human IL-10 and IL-4 promoter regions and gastric cancer event, besides the level of cytokines, like IL-10, TNF-α and IFN-γ, being similar in patients and healthy individuals, the present research provides insight into two possible biomarkers of immunological nature (increased level of serum IL-4) and genetic nature (presence of the IL-10, −G1082A SNP) related to this neoplasm in our population. Here, IL4 is linked to gastric cancer.