Similarly, description has been made of another coadjuvant role of tumor establishment and metastasis by infiltrating myeloid cells (CD11b+), given the production of L-phenylalanine oxidase IL-4 induced gene 1 (IL-4I1), inversely correlated with the presence of cytotoxic T CD8+ subpopulations and melanoma control [67]. This evidence concerns the gene ITGAM and melanoma.