An important role of Th2 profile cytokines, such as IL-4, in the polarization and activation of M2 macrophages (with tolerogenic function or incapable of activating the T lymphocyte response) has been described, favoring their pro-tumor function or neoplasm progression due to the production of IL-10 (among other molecules) that suppresses the function of other immune cells of great relevance as the cooperating (CD4+) and cytotoxic (CD8+) T lymphocytes [17, 18]. Here, CD8A is linked to neoplasm.