Shibata et al. [59] had already shown a decrease in the level of Th1 profile cytokines, like IL-12, in a group of patients with gastric carcinoma (25 cases ranging in age from 32 to 82 years) and advanced colorectal, more significant in those with evidence of metastasis and cachexia, along with a progressive increase for this last group in the level of Th2 profile cytokines, like IL-4 and IL-10, agreeing with diminished Th1/Th2 balance (P < 0.05). This evidence concerns the gene IL4 and gastric carcinoma.