IL4 and neoplasm: In this regard, an association has been established between a SNP in (C to T) -590 in the promoter region of the IL-4 [24], leading to overexpression of this cytokine, with increased risk of developing cardiac subtype (OR = 2.44) or diffuse gastric carcinoma (OR = 1.64) [15]; this may be poorly differentiated and considered metastatic [25], in contrast with that reported, for example, for another point mutation variant in this same region, like − 168 (T/C), associated to lower risk of developing this neoplasia (cardiac subtype) [26].