We and others had also shown previously that MYC is able to suppress activated RAS- and BRAFV600E-induced senescence in primary rodent cells in culture as well as BRAFV600E-induced senescence in transgenic mouse tumor models, which was linked to upregulation of cell cycle genes and repression of p16 and p21 [13,15,20]. This evidence concerns the gene MYC and neoplasm.