Furthermore, CTSB has been described in some settings to directly cleave caspase‐1 and caspase‐11, mediating both canonical and non‐canonical pyroptosis.55, 56 In the third mode, the NLRP3 agonist (eg, HG, hyperlipidaemia) triggers the production of reactive oxygen species (ROS) and further activates the NLRP3 inflammasome.58 This evidence concerns the gene NLRP3 and hyperlipidemia.