TXNIP and Hyperglycemia: Hyperglycaemia‐induced ROS overproduction promotes the activation of the NLRP3 inflammasome by NF‐kB and thioredoxin‐interacting protein (TXNIP).16 TXNIP, also known as thioredoxin binding protein‐2, is a ubiquitously expressed protein that interacts and negatively regulates the expression and function of thioredoxin (TXN).