Caspase‐1 and IL‐1β expression levels are significantly up‐regulated in hypertrophic cardiomyocytes both in vivo and in vitro, and the inhibition of caspase‐1 can mitigate cardiac hypertrophy induced by angiotensin II, which offers a therapeutic potential against cardiac hypertrophy.93 This evidence concerns the gene IL1B and cardiac hypertrophy.