LGALS3 and rheumatoid arthritis: Associations between increased galectin-3 in synovial fluid, synovial tissues, and sera of human patients with inflammatory arthritis have been observed in several studies (7–9), and strong expression of galectin-3 at sites of joint destruction has led authors to suggest that galectin-3 plays a role in rheumatoid arthritis (RA) pathogenesis (10).