This corresponds to a greater induction of IFN-gamma, TNF-alpha and IL-2 in response to MOLM-14 as compared to HL-60 tumor cells, and a greater induction in response to HL-60 vs. KG-1a (Figure 3), and also correlates with the relative cytotoxic activity of the anti-CD33 CARs against these cell lines (Figure 4). Here, TNF is linked to neoplasm.