IFNG and neoplasm: CAR33VH and My96CAR elaborated high levels of IFNγ, TNFα, and IL-2 in response to CD33high tumor lines MOLM-14 and HL-60, whereas CAR T-secreted cytokines were not significantly induced when challenged with CD33moderate line KG-1a (Figure 3), or CAR T cells incubated alone, demonstrating antigen specificity.