With these cut-off values, Nu-SIRT6-positivity was significantly associated with elevated preoperative serum level of CA125, higher tumor stage, presence of ascites, bilaterality of the tumor, higher histologic grade, platinum resistance, and the expressions of Cy-SIRT6, Nu-Aβ-catenin, and Cy-Aβ-catenin (Table 2). The gene discussed is SIRT6; the disease is neoplasm.