TNKS2 and neoplasm: In addition, previous studies demonstrated that the Wnt/β‐catenin signaling pathway also participated during cancer cell EMT 26, 27, accompanied by downregulated epithelial markers, E‐cadherin and keratin, and upregulated mesenchymal markers such as N‐cadherin and vimentin, while tankyrase 2 (TNKS2) plays an important role in tumor cell migration and invasion 28 and TNKS2 inhibition was able to downregulate activity of the Wnt/β‐catenin signaling pathway and thereby reduce tumor cell growth 29.