During the 30‐day period, tumor volumes increased in all of the mice; however, the growth speed of CRL1623‐IL‐18 xenografts was slower and the tumor xenograft volumes were smaller in size compared with those of the CRL1623‐vec‐injected mice (P < 0.05; Fig. 3B), thus indicating an inhibitory effect of IL‐18 on TSCC cells. This evidence concerns the gene IL18 and neoplasm.