TNKS2 and neoplasm: Therefore, we supposed that IL‐18 overexpression could activate β‐catenin signaling by stimulation of TNKS2 expression, resulting in the switch between E‐cadherin and N‐cadherin expression, namely increase in N‐cadherin expression but decrease in E‐cadherin expression to reverse the ratio of E‐cadherin to N‐cadherin and induced tumor cell EMT.