SIPA1 and Splenomegaly: Importantly, transplantation of normal Sipa1+/+ hematopoietic cells in Sipa1−/− recipients was followed by neoplastic transformation in MDS/MPN, recapitulating the same disease features observed in aged Sipa1−/− mice, including anemia, increased granulocytes, pronounced B-lymphopenia, and splenomegaly [72].