Our findings demonstrate that GM6 significantly alters the expression of > 2800 protein-coding genes in SH-SY5Y neuroblastoma cells, leading to expression responses consistent with activation of multiple neurodevelopmental signaling pathways (e.g., Notch and Hedgehog), increased abundance of proteins contributing to the extracellular matrix or cell adhesion (COL1A1, COL6A2, COL26A1), and modulation of chromatin structure and a network of transcription factors interacting with cis-regulatory elements (STAT3, HOXD11, HES7, GLI1). This evidence concerns the gene GLI1 and neuroblastoma.