We had already shown that pretreatment of either aortic rings and isolated mesenteric beds removed from DOCA-hypertensive rats with chelerythrine can significantly improve the endothelial dysfunction (21), to investigate the effectiveness of chelerythrine in other states of endothelial dysfunction, such as septic shock, isolated kidneys were preincubated with chelerythrine, a PKC inhibitor. The gene discussed is PRRT2; the disease is endothelial dysfunction.