FBP1 and hepatocellular carcinoma: The common feature of these alterations is an increased glucose uptake and production of lactate even in the presence of oxygen and fully functioning mitochondria (Warburg effect) [2, 3], but it is not correlated with enhanced gluconeogenesis as the expression of phosphoenolpyruvate carboxykinases 1 and 2 and fructose 1,6-bisphosphatase 1 (FBP1), has been reported to be downregulated in HCC [14].