In addition, another study found that paeonol abated macrophages switching into foam cells not only through promoting the efflux of ox-LDL by maintaining stabilization of ABCA1 but also via blocking the cholesterol uptake by abolishing c-Jun-mediated CD36 synthesis and then leading to attenuation of atherosclerosis burden in apoE−/− mice [68]. The gene discussed is ABCA1; the disease is atherosclerosis.