HMOX1 and left ventricular hypertrophy: Genetic engineering also extends its application to modify MSCs by overexpressing receptors and proteins for regenerative medicine: CXCR4 to take advantage of SDF-1 chemotaxis; fibroblast growth factor-2 (FGF2) for improved viability after transplantation into injured myocardium; heme oxygenase-1 (HO-1) to improve cell survival, organ recovery, and function in injured heart; and vascular endothelial growth factor (VEGF) for angiogenesis and inhibition of progression of left ventricular hypertrophy [21, 22].