As suggested earlier, IFN-γ, IL-6, and TNF-α are the critical proinflammatory elements produced in response to neuroinflammation [33–35], Thus, a significant reduction in the levels of these proinflammatory markers in this study suggests the antineuroinflammatory role of simvastatin in LPS-activated C6 glioma cells. This evidence concerns the gene TNF and glioma.