The polymorphisms at PRSS1-PRSS2 rs10273739, which influence trypsinogen expression, and MORC4 rs12688220, which associate with atypical localization of cludin-2 in pancreatic acinar cells, are associated with acute pancreatitis [5], related recurrent acute pancreatitis, and chronic pancreatitis [3, 4]. This evidence concerns the gene MORC4 and acute pancreatitis.