Even though previous clinical studies demonstrated that several oligodendroglia and myelin related genes were significantly associated with major mental illnesses, such as MAG (Wan et al., 2005; Voineskos et al., 2013), Olig2 (Georgieva et al., 2006; Mitkus et al., 2008), and CNP (Voineskos et al., 2008), the function of a majority of schizophrenia related genes was poorly explored in oligodendroglia, which in turn hampers the understanding of pathological mechanisms of causal genes in oligodendroglia. This evidence concerns the gene OLIG2 and psychiatric disorder.