CTLA4 and cytomegalovirus infection: Similarly as previously validated for EBV pathologies in humanized mice (53), this novel HCMV infection model and advanced multivariate analyses systems can be used as proof-of-principle to evaluate innovative immune therapies such as check-point inhibitors blocking PDL-1 and CTLA-4.n the future, it will be interesting to evaluate the effects of HCMV infections in immune deficient mouse strains expressing human MHCs or multiple human cytokines (54).