In contrast, LN showed a deviant pattern, as primary infections suppressed the development of IgG+ memory B cells (REAC vs. INF p < 0.01, Table S7B, Figure 5A) and reactivations pushed significantly the development of mature PB, PC, and IgG+ B cells (Figure 5A, Table S7B, Figure S6A). The gene discussed is CBLIF; the disease is infection.