CD4 and cytomegalovirus infection: More recently, using a short-term 12 weeks NSG/BLT model of HCMV infection (clinical strain TRpM1A or laboratory strain TB40/GFP), the same group detected human CD4+ and CD8+ T cell responses against the viral immediate early protein 1 (IE1) and the phosphoprotein pp65 and humoral human responses with the ability to neutralize HCMV in vitro (25).