Here we investigated the function of endogenous heart APC subsets and their contribution to regulating the heart-specific immune response by using α-myosin-specific CD4+ T cell receptor (TCR) transgenic T cells (TCR-M cells) as readout of antigen presenting function (35), and induction of EAM as readout of pathogenic autoimmunity. This evidence concerns the gene CD4 and Autoimmunity.