Antiphospholipid Syndrome (APS) is an autoimmune disorder characterized by thrombosis and/or pregnancy morbidity in presence of persistent antiphospholipid antibodies such as lupus anticoagulant (LA), isotype IgG and/or IgM for anti-beta-2-glycoprotein I (aB2GPI) and anti-cardiolipin antibodies (aCL) (1–4). The gene discussed is CD40LG; the disease is antiphospholipid syndrome.