When IECs were exposed to either the Lr-CFS or Lh-CFS without any innate immune stimulants, there were no alterations in the constitutive production of IL-8 or CINC-1 from HT-29 or IEC-6 IECs, respectively. The gene discussed is CXCL8; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.