When exposed to obesity-associated metabolic conditions, we show that adipocytes increase the secretion of resistin, together with inflammatory mediators (C-reactive protein, endocan and EN-RAGE) and extracellular matrix regulating factors (Serpin A8, TIMP-1, and TIMP-3), which may contribute to the biological effects observed. Here, TIMP3 is linked to obesity due to melanocortin 4 receptor deficiency.