ATF6 and overnutrition: Interesting, Oben et al. reported that maternal obesity modified the hepatic UPR rhythmicity with Atf6 activation during the day, which was aggravated by the double obesogenic hit (combination of intrauterine and postpartum obesogenic diets) (23).Both intrauterine nutrition deficiency and overnutrition trigged upregulated ATF6, indicating that ATF6 play an important role in the pathogenesis of developmental origins of NAFLD.