Graham et al. found that in the placenta of mice with eukaryotic initiation factor 2α (eIF2α)-overexpression, UPR was enhanced, impairing placental function and leading to the development of IUGR (24); UPR factors were also enhanced in adipose tissues of foetuses with IUGR caused by a uterine artery clamp. This evidence concerns the gene EIF2A and fetal growth restriction.