Immunoblotting also showed that the protein levels of Hspa4l, Creb3l1, and Mapk10 decreased significantly in IUGR foetuses (E20) compared to age-matched controls, while the levels of Creb3l3 protein increased remarkably (Figure 6A and Table 4), consistent with the mRNA data. The gene discussed is CREB3L3; the disease is fetal growth restriction.