Numerous studies have systematically conceptualized that abnormalities of 5-HT1 (5-HT1A, 5-HT1D) and 5-HT2 (5-HT2A, 5-HT2C) receptors in the central nerve system may account for the manifestation of MDD (Hamon and Blier, 2013; Nautiyal and Hen, 2017). This evidence concerns the gene HTR2A and major depressive disorder.