The balance between the classical RAS pathway, i.e., the ACE/Ang II/AT1R axis, and the “non-classical” RAS pathway, i.e., the ACE2/Ang-(1-7)/Mas receptor axis, probably plays an important role in the pathogenesis of many ailments, especially kidney diseases (Gironacci et al., 2014). The gene discussed is ACE; the disease is kidney disorder.