To determine whether dCSF-CNs plays a role in renal NADPH oxidase production and inflammation induced by CKD, protein levels of NOX2, catalase, and inflammatory cytokines (MCP-1 and IL-6) were compared between 5/6Nx rats without dCSF-CNs ablation and the rats with dCSF-CNs lesions. This evidence concerns the gene IL6 and chronic kidney disease.