These results are consistent with previous studies, which showed that the DKK1 inhibited the proliferation of several types of cells, including human retinal pigment epithelial cells, periosteal cells, osteosarcoma cells, via downregulation of Wnt/β-catenin signaling pathway (Kim H.K. et al., 2013; Liu et al., 2014; Zhou et al., 2016). The gene discussed is DKK1; the disease is osteosarcoma.