HIF1A and bacterial infectious disease with sepsis: Its expression is controlled both transcriptionally and post-translationally during bacterial sepsis, with previous studies having demonstrated that HIF-1α in myeloid cells plays a key role in regulating proinflammatory gene expression and cytokine production, as well as the mortality and clinical symptomatology of both gram negative (Peyssonnaux et al., 2007) and gram positive (Mahabeleshwar et al., 2011) sepsis.