SGK1 and hypertensive disorder: For example, it has been reported that a modest increase in salt concentration induces SGK1 expression, promotes IL-23R expression, and enhances Th17 cell differentiation in vitro and in vivo (Wu et al., 2013), and that SGK1 signaling in T cells promotes hypertension and contributes to end-organ damage (Norlander et al., 2017).