AGT and Hypertension: Furthermore, it has been shown that SGK1 contributes to cardiac inflammation and fibrosis by mediating nucleotide-binding oligomerization domain-like receptor with pyrin domain 3 (NLRP3) inflammasome activation (Gan et al., 2018), and cardiac fibroblast-to-myofibroblast transition in AngII-induced hypertension (Yang et al., 2012).