Recent studies suggest that SGK1 mediates AngII-induced sodium reabsorption via sodium-hydrogen exchanger-3 (NHE3) expression and Na+ reabsorption in proximal tubular cells (Vallon et al., 2006; Stevens et al., 2008), and renal fibrosis by stimulating connective tissue growth factor (CTGF) expression in human kidney fibroblasts (Hussain et al., 2008). The gene discussed is CCN2; the disease is renal fibrosis.