TNF and hypertensive disorder: This finding is consistent with previous studies showing that peripheral cytokines such as IL-17, IL-6, IL-1β, Interferonγ (IFN-γ), monocyte chemoattractant protein 1 (MCP-1), vascular endothelial growth factor (VEGF), and TNF-α were increased and contributed to target organ damages in AngII-induced hypertension in mice (Lee et al., 2006; Sanchez-Lemus et al., 2009; Madhur et al., 2010; Mirhafez et al., 2014; Park et al., 2017).