NFE2L2 and hepatocellular carcinoma: Ras transformation is demonstrated to render cells sensitive to ROS-induced ferroptosis; however, in some cases RAS-driven nuclear factor erythroid 2-related factor 2 (NRF2) activation can enhance the expression of antioxidant genes that protects hepatocellular carcinoma (HCC) cells against ferroptosis (Schott et al., 2015; Sun et al., 2016).