To investigate potential signaling molecules or pathways involved in EPRS-mediated regulation of ECM protein synthesis following TGFβ1-treatment, we studied the dependency of STAT3 and STAT6, known mediators of IPF (Nikota et al., 2017; Milara et al., 2018), on EPRS expression. This evidence concerns the gene TGFB1 and idiopathic pulmonary fibrosis.