In addition to IL8, which is used to characterize IPF (Carre et al., 1991), Col1a1, Fn1, and Lamc2 mRNA levels were also upregulated by bleomycin treatment in Eprs+/+ lungs but not Eprs−/+ hetero-KO lungs (Figure 5C). The gene discussed is FN1; the disease is idiopathic pulmonary fibrosis.