Overexpression of family-with-sequence-similarity-46C (FAM46C) reportedly inhibits invasiveness of liver cancer cells by suppressing transforming growth factor-β-Smad signaling and EMT; FAM46C-knockout can change the anti-metastatic effect of NCTD on tumor cells, suggesting the anti-hepatoma impact of NCTD is affected by up-regulating FAM46C (Wan et al., 2017). The gene discussed is TENT5C; the disease is hepatocellular carcinoma.