Tian et al. found that astragalus polysaccharides increased sensitivity of H22 HCC cell lines resistant to Adriamycin (H22/ADM cell lines) to chemotherapeutic agents, which may be related to downregulation of P-glycoprotein and MDR1 mRNA expression (Tian et al., 2012a). The gene discussed is ABCB1; the disease is hepatocellular carcinoma.