MAPK3 and neoplasm: Lam et al. discovered Huangqin and Shaoyao, which are the two main components of PHY906, might change the inflammatory state of tumor microenvironment and enhance the anti-tumor effect of sorefenib by inhibiting ERK1/2 phosphatase and thus increasing ERK1/2-P in HepG2 cells (Lam et al., 2015).