MAPT and Alzheimer disease: Additionally, preclinical studies have found that glucocorticoids and corticotrophin-releasing hormone (CRH) were involved in AD pathogenesis by manipulating the levels of Aβ and tau pathologies (Kulstad et al., 2005; Green et al., 2006; Jeong et al., 2006; Filipcik et al., 2012; Rothman et al., 2012).