MAPT and Alzheimer disease: In comparison to other experiments with mice carrying amyloid and tau mutations which did not focus on behavior (Lewis et al., 2001; Pérez et al., 2005; Bolmont et al., 2007; Paulson et al., 2008), this mouse was examined on several important behaviors affected in the AD patient: cognitive, emotional, and activities of daily living (ADL) at both early and later stages of disease progression.