Examples of mouse models modeling both amyloid and tau pathology include the Tg2576/JNPL3 cross (Lewis et al., 2001), crosses of the Tg2576 and VLW(tau) mice (Pérez et al., 2005; Ribé et al., 2005), hAPP (Swe)/wildtype human Tau (Chabrier et al., 2014), hAPPNLI/Tau(P301L) (Paulson et al., 2008), APP23/B6P301L (Bolmont et al., 2007), APP-V717I/TauP301L (Terwel et al., 2008), and the 3xTg-AD mouse (Oddo et al., 2003). The gene discussed is APP; the disease is Alzheimer disease.