Among these members, the VEGF-A family is the most potent inducer of new vessel formation; more specifically, the pro-angiogenic VEGF165a isoform has a prominent role in neovascularization, and vessels permeability-related eye diseases, such as age-related macular degeneration (AMD) and diabetic retinopathy (DR) (Ferrara et al., 2003; Bandello et al., 2013; Amadio et al., 2016a). This evidence concerns the gene VEGFA and age-related macular degeneration.