TP53 and open-angle glaucoma: In particular, some evidence indicates that the p53 codon 72 polymorphism may be associated with increased risk of POAG in Asian but not in Caucasian populations (Guo et al., 2012; Neamatzadeh et al., 2015; Gohari et al., 2016), while others have not confirmed these results (Mabuchi et al., 2009).