In DBA2J mice, where glaucomatous-like ON pathology is directly linked with failure of mitochondrial bioenergetics and decreased Ngb content, exogenous delivery of Ngb can slow down progression of RGC degeneration or even reverse it, which brings up a promising application in mitochondrial ON diseases, i.e., LHON (Cwerman-Thibault et al., 2017). This evidence concerns the gene NGB and Leber hereditary optic neuropathy.