Recently, Oakes et al. have demonstrated that ADAR3 directly competed with ADAR2 for binding to GRIA transcript and inhibited RNA editing at the Q/R site of GRIA2 in glioblastoma [14], and this editing position of GRIA2 was substantially underedited in malignant human brain tumors compared with control tissues [25]. This evidence concerns the gene GRIA2 and brain neoplasm.