sFRP-5 is a potent anti-inflammatory molecule that modulates metabolic dysfunction in obesity by binding and sequestering Wnt5a preventing its ability to activate the Wnt signaling pathway [11], and regulation of its levels by LRP1 provides a plausible mechanism for the effects we are noting in LDLR−/−; macLRP1−/− mice. The gene discussed is LRP1; the disease is obesity due to melanocortin 4 receptor deficiency.