Moreover, asprosin level was positively correlated with HOMA-IR in T2DM and its normal-weight subgroup (P < 0.05 or P < 0.01) and negatively correlated with OGTT-120 min insulin in the normal-weight subgroup and with HDL-C in the overweight subgroup (P < 0.05). Here, INS is linked to type 2 diabetes mellitus.