SHBG and polycystic ovary syndrome: In addition, in normal-weight PCOS subjects, asprosin still had a positive correlation with estradiol secreted by ovarian granulocytes but was negatively correlated with SHBG, a transporter for most of the estradiol in blood (P < 0.05 or P < 0.01), suggesting that asprosin level might be an indirect trigger or just an indicator of metabolic and sex-related hormone dysfunction.