HLA-G and infection: Overall, our data show for the first time that HHV-6A and 6B infections induce up-modulation and release of HLA-G in human endothelial cells, and that this remodulation, in particular the release of the soluble HLA-G isoform from infected cells, is directly related to the inhibition of angiogenetic properties observed in ECs upon HHV-6 infection.