PIWIL2 and neoplasm: In multivariate analysis (adjusted to tumor grade and tumor stage), the Piwi-like 2-positive group had a 8.9-fold increased risk of death, a 16.9-fold increased risk of disease-specific death and a 9.4-fold increased risk for recurrence compared to the Piwi-like 2-negative group (P = 0.004; P = 0.011 and P = 0.028; Table 3), i.e., also Piwi-like 2 staining was an independent prognostic factor in the squamous differentiated subtype of BCa.