Compared with the paired non-tumor liver tissues, significant up-regulation of CCRK, p-GSK3βSer9/GSK3β, p-mTORSer2448/mTOR, p-4E-BP1Thr37/46/4E-BP1, p-S6KThr389/S6K, mSREBP1, G-CSF, p-STAT3Tyr705/STAT3, and AR were detected in HCC tissues (p < 0.05; Fig. 7b). This evidence concerns the gene CSF3 and hepatocellular carcinoma.