Given the critical role of GSK3β, the direct substrate of CCRK24 on mTOR signaling in obesity-associated HCC20,22, it is conceivable that the CCRK/GSK3β cascade regulates mTORC1 signaling to promote obesity-associated hepatocarcinogenesis. The gene discussed is CDK20; the disease is obesity due to melanocortin 4 receptor deficiency.