Strikingly, when compared to shCtrl controls, Ccrk knockdown significantly reduced > 70% obesity-promoted tumor multiplicity and size in HFHC-fed mice (p < 0.01; Fig. 2e, f) but not in CD-fed mice (Supplementary Fig. 2a, b). The gene discussed is CDK20; the disease is obesity due to melanocortin 4 receptor deficiency.