Lentiviral shRNA-mediated down-regulation of Raptor (shRaptor) in the livers of TG mice (Supplementary Fig. 5c) abolished tumor growth (p < 0.05; Fig. 6d), which was associated with significant reduction in PMN-MDSCs (p < 0.05; Fig. 6e). The gene discussed is RPTOR; the disease is neoplasm.