INS and Glucose intolerance: Lentiviral shRNA-mediated down-regulation of Ccrk (shCcrk) in the livers of the obese mice nearly restored the plasma triglyceride and NEFA concentrations to the basal levels (p < 0.05; Fig. 1c), and reversed the glucose intolerance and insulin resistance when compared to the control mice treated with lentivirus expressing non-specific sequence control (shCtrl; p < 0.01; Fig. 1d, e).