In contrast, the HFHC-fed female C57Bl/6 mice did not exhibit CCRK induction (Supplementary Fig. 1a), triglyceride/NEFA abnormalities (Supplementary Fig. 1b–c), or glucose intolerance (Supplementary Fig. 1d), although the weight gain was comparable to the male counterparts (Supplementary Fig. 1e). Here, CDK20 is linked to Glucose intolerance.