We also observed that aab directed against structurally and functionally related molecules, such as anti-angiotensin II receptor type 1 or AGT1R and EDNRA (Fig. 1d–i), cholinergic receptor muscarinic (CHRM) 1–4 (Fig. 1j), protease-activated receptors (coagulation factor II thrombin receptor or F2R and the coagulation factor II thrombin receptor-like 1 or F2RL1) (Fig. 1k), and chemokine (C-X-C) motif receptor 3 (CXCR3) and 4 (Fig. 1l), correlated strongly in HD. Here, F2RL1 is linked to Huntington disease.