While only SLE abrogated the normal interconnection between anti-AGTR1 and anti-EDNRA (Fig. 1e–i), the correlation among anti-CHRMs was reduced in SLE and GPA, whereas the partnership of aab directed against F2R and FRL1 was abolished in SLE, SSc, and GPA. The gene discussed is AGTR1; the disease is systemic lupus erythematosus.