Considering the central role of interleukin-8 (IL-8) as an important chemokine that regulates neutrophil migration29, we were able to show that HD-IgG triggered IL-8 production by peripheral blood mononuclear cells (PBMCs) (Fig. 8d), which also express EDNRA32. The gene discussed is CXCL8; the disease is Huntington disease.