Investigation of the CDKN2B-AS1 expression in several colon epithelial cell lines, including NCM460, HCT116, and DLD-1, showed a positive correlation with N-myc as an important regulatory transcription factor, which was also confirmed in IBD patient samples (R2: 0.691; P value: 0.004304). Here, CDKN2B is linked to inflammatory bowel disease.