Likewise, a negatively correlated model between CREB1, CCAR1, JNK1 and miR-433 was observed when we up- or down-regulated miR-433 through transient or stable transfection in CRC cells at the mRNA and protein level (Supplementary Figure S1a-b and Figure 4e). This evidence concerns the gene CREB1 and colorectal carcinoma.