Overexpression of miR-433-3p inhibited CREB1, CCAR1 and JNK1 expression in CRC cells, with an accompanying downregulation of phospho-Smad2, phospho-c-Jun, CDK2, vimentin, snail and slug and upregulation of p21, p27, E-cadherin and β-catenin (Figure 6b). This evidence concerns the gene SMAD2 and colorectal carcinoma.