TNF and cancer: The 171 drug target genes from DrugBank [23] (S2 Table) corresponding to drugs approved for cancer treatment demonstrated a significant overlap with the 41 DEGs related to B-cell infiltration and PD-L1; that is, four genes overlapped (10.78-fold enrichment by a permutation analysis, p = 6e-04; Fig 5B), namely interleukin 2β receptor (IL2RB), interleukin 2γ receptor (IL2RG), Toll-like receptor 8 (TLR8), and TNF (Fig 5C).