In addition, and relative to the overall inhibition of the ETS in the therapeutic hypothermia temperature, the larger magnitude reduction in the activity of complex II may minimize deleterious ROS generation during reperfusion that has been linked to succinate accumulation during ischemia [34], whereas the significant reduction in complex V activity may help to minimize ATP consumption through reverse-flow of the ATPase [35], and thus contribute to the retention of energy stores during low oxygen stress. Here, DNAH8 is linked to ischemia.