Our findings are consistent with the notion that changes in IL-6 in individuals with systemic inflammation related to autoimmune disorders (but also possibly to infections or other inflammatory diseases) may display blunted IKr with serious implications for cardiac repolarization especially in the setting of other known classical risk factors including electrolytes imbalance, QTc prolonging medications, genetic and autoimmune channelopathies [22]. Here, IL6 is linked to autoimmune disease.