IL10 and ischemia: Interestingly, while some investigators observed decreased intestinal IL-10 expression[61–63] and decreased tissue expression of IL-10 in skin wounds in GF mice,[8] others have shown that GF mice have an attenuated local and systemic response to intestinal ischemia/reperfusion injury that corresponds to marked increases in endogenous IL-10 production at both the local (intestines) and remote (lung) tissue level[40].